Peculiarities of use of Emetrol (domperidone)

Emetrol is widely used in the treatment of diseases of the gastrointestinal tract. Chronic gastritis is a long-term recurrent lesion of the gastric mucosa, proceeding with its structural rearrangement and violation of its secretory (acid- and pepsin-forming) motor and incretory (synthesis of gastrointestinal hormones) functions of the stomach. Despite the fact that in chronic gastritis of the stomach in a large proportion of cases etiological factors remain unidentified, Helicobacter pylori is increasingly suspected in the development of this disease, because its role in mucosal damage is no longer doubt. This bacterium causes antral gastritis and pangastritis, so certain groups of drugs, including antibiotics, are used to treat gastritis of bacterial etiology. Unfortunately, eradication of Helicobacter pylori does not always lead to relief of symptoms accompanying gastritis. One of the problems of gastritis therapy is that the efforts of doctors are primarily aimed at fighting the bacterial infection, often forgetting about the need to eliminate the symptoms of motility disorders. Symptoms manifest themselves as a feeling of bloating and heaviness in the abdomen after a meal. In addition, motility disorders of the upper gastrointestinal tract are often accompanied by nausea and, less frequently, vomiting. To eliminate such symptoms, a separate drug with a different principle of action is needed to help normalize gastric motility.

Peculiarities of use of Emetrol (domperidone)

The drug Emetrol (domperidone) is used to correct motility disorders, which are most often associated with such symptoms as bloating and a feeling of heaviness after eating, belching, nausea, vomiting. This medication affects the key mechanisms of motility disorders. Emetrol improves coordination between contractions of the antral stomach and duodenum, ensuring normal evacuation from the stomach and preventing duodenogastric reflux. At the same time, the drug does not affect hydrochloric acid secretion, gastric pH values and serum gastrin levels.

Important! Emetrol (domperidone) has proven to be an effective agent in the complex therapy of gastritis with motility disorders. Administration of the drug promotes the disappearance of such accompanying symptoms of gastritis as a feeling of fullness in epigastrium, early satiety, abdominal bloating, nausea, vomiting, belching, and a feeling of discomfort in the epigastric region. When fighting the culprit of gastritis, the bacterium Helicobacter pylori, the symptoms of discomfort that accompany the disease should not be neglected.

How does Emetrol work?

Peculiarities of use of Emetrol (domperidone)

Emetrol (domperidone) helps to eliminate the unpleasant symptoms that accompany chronic gastritis with impaired motility. The active ingredient of the drug, domperidone, is an antagonist of peripheral dopamine receptors localized in the wall of the stomach and duodenum. Besides, the drug increases tone and pressure of lower esophageal sphincter, accelerates gastric emptying, increases duodenal peristalsis and increases duration of antral and duodenal contractions. In addition, gastrokinetic action of Motilium increases antiemetic effect, which is due to blockade of dopamine receptors located in the chemoreceptor trigger zone on the floor of the fourth ventricle.