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LOESTRIN (Ethinyl Estradiol, Norethisteron) 


 

Pharmacodynamics:

Pharmacological action - estrogen-gestagen.


It replenishes the endogenous hormone deficiency. Regulates the metabolism of proteins, fats and carbohydrates, water-electrolyte balance, reduces LDL and cholesterol in the blood, maintains the normal structure of bone tissue, improves mood, increases libido.


Pharmacokinetics:

Ethinyl Estradiol, Norethisteron. After oral intake is absorbed from the gastrointestinal tract. It is subjected to the effect of the first passage through the liver. Metabolized to less active metabolites - estriol and estroline. Metabolites are secreted by the kidneys, a small part - through the intestines.


After oral intake of noretisterone, acetate is quickly absorbed and converted to noretisterone. Time to reach maximum concentration is 0.5-1.5 h, which is 3.9 ng/ml (1.4-6.8 ng/ml). Bonding with proteins: with albumins - 61 %, globulins - 36 %. The half-life period is 8-11 hours.


Metabolized in the liver with the formation of 5-alpha-dihydro-noroethysterone and tetrahydro-noroethysterone, which are derived mainly from urine in the form of sulfate and glucuronide conjugates.


Readings:

Estrogen deficiency in menopausal period, relief of menopausal symptoms, prevention of osteoporosis in menopause.


ICB-10

Ethinyl Estradiol, Norethisteron Contraindications:

Hormone-dependent tumors (breast carcinoma or endometrium), acute or chronic liver diseases (including history), deep vein thrombosis, thromboembolism, circulatory disorders (including history), uterine bleeding of obscure etiology, hemoglobinopathy, porphyria.



Careful:

Appointed with caution in hypertension, epilepsy, migraine, diabetes mellitus, bronchial asthma, heart failure (patients should be under medical supervision). Experience in treatment of women over 65 years of age is limited.


Pregnancy and lactation:

Contraindicated for pregnancy and lactation.


How to use and Ethinyl Estradiol, Norethisteron Dosage:

The pills are designed for continuous combined hormone replacement therapy in women with an unwanted uterus. The drug is taken orally 1 tablet a day without interruption, preferably at the same time of day.


In the treatment of symptoms of postmenopause, the drug should begin and resume at the lowest effective dose for short-term therapy.


If the response to therapy is insufficient, the transition to a higher-dose drug should be discussed after three months.


Patients with amenorrhoea who are not receiving hormone replacement therapy or are taking another combination drug on a continuous basis may start taking the tablets on any convenient day. When transferring patients from a cyclic regime of hormone replacement therapy, treatment should begin immediately after the end of menstrual bleeding caused by the drug withdrawal.


If you miss the next tablet, the missed pill should be taken as soon as possible within the next 12 hours. If the medication is more than 12 hours late, the missed tablet should be discarded. Missing another dose may cause uterine bleeding to break through or cause bleeding to appear. Dispose of unused medication according to local requirements.



 

 

 

 

 

 

 

 

 

 

 

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