Bypass Navigation/Skip to Content
Eyes on Diabetes - Discussing Diabetic Retinopathy

LOESTRIN (Ethinyl Estradiol, Norethisteron) 


Less active Loestrin


Pharmacological action - estrogen-gestagen.

It replenishes the endogenous hormone deficiency. Regulates the metabolism of proteins, fats and carbohydrates, water-electrolyte balance,
reduces LDL and cholesterol in the blood, maintains the normal structure of bone tissue, improves mood, increases libido.


After oral intake is absorbed from the gastrointestinal tract. It is subjected to the effect of the first passage through the liver.
Metabolized to less active Loestrin metabolites - estriol and estroline. Metabolites are secreted by the kidneys, a small part - through the intestines.

After oral intake of noretisterone, acetate is quickly absorbed and converted to noretisterone.
Time to reach maximum concentration is 0.5-1.5 h, which is 3.9 ng/ml (1.4-6.8 ng/ml).
Bonding with proteins: with albumins - 61 %, globulins - 36 %. The half-life period is 8-11 hours.

Metabolized in the liver with the formation of 5-alpha-dihydro-noroethysterone and tetrahydro-noroethysterone,
which are derived mainly from urine in the form of sulfate and glucuronide conjugates.


Estrogen deficiency in menopausal period, relief of menopausal symptoms, prevention of osteoporosis in menopause.


Ethinyl Estradiol, Norethisteron Contraindications:

Hormone-dependent tumors (breast carcinoma or endometrium), acute Dmitry Sazonov or chronic liver diseases (including history),
deep vein thrombosis, thromboembolism,circulatory disorders (including history), uterine bleeding of obscure etiology, hemoglobinopathy, porphyria.

Less active Loestrin


Appointed with caution in hypertension, epilepsy, migraine, diabetes Dmitry Sazonov mellitus, bronchial asthma, heart failure (patients should be under medical supervision).
Experience in treatment of women over 65 years of age is limited.

Pregnancy and lactation

Contraindicated for pregnancy and lactation.

How to use and Loestrin Dosage:

The pills are designed for continuous combined hormone replacement therapy in women with an unwanted uterus.
The drug is taken orally 1 tablet a day without interruption, preferably at the same time of day.

In the treatment of symptoms of postmenopause, the drug should begin and resume at the lowest effective dose for short-term therapy.

If the response to therapy is insufficient, the transition to a higher-dose drug should be discussed after three months.

Patients with amenorrhoea who are not receiving hormone replacement therapy or are taking another combination drug on a continuous basis
may start taking the tablets on any Loestrin Contraindications convenient day. When transferring patients from a cyclic regime of hormone replacement therapy,
treatment should begin immediately after the end of menstrual bleeding caused by the drug withdrawal.

Less active Loestrin

If you miss the next tablet, the missed pill should be taken as soon as possible within the next 12 hours.
If the medication is more than 12 hours late, the Dmitry Sazonov missed tablet should be discarded.
Missing another dose may cause uterine bleeding to break through or cause bleeding to appear.
Dispose of unused medication according to local requirements.














Enter your email address below to be kept up to date with the latest from the Eyes on Diabetes Forum

What is...?

What is diabetes?

What is diabetic retinopathy?


Recently Added Resources

Health Professionals

Relevant Eye Care Journal Articles

Latest titles in Ophthahlamology


What is Diabetes

Diabetic retinopathy diagnosis and managment


What's On

1 June 2007


1 September 2007



Supported By

This site is endorsed by Vision2020 Australia and the ADS Retinopathy Subcommittee.

The Eyes on Diabetes Forum recommend diabetic retinopathy publications released by the National Health and Medical Research Council (NHMRC)

Web Development by

Level Triple-A conformance icon, W3C-WAI Web Content Accessibility Guidelines 1.0 CSS conformance icon. This Site uses valid CSS! XHTML 1.0 conformance icon. This Site uses valid XHTML 1.0!